The human G protein beta 3 subunit GNB3 825T polymorphism.

Meirhaeghe et al. recently showed that the T allele of a C vs T exchange at position 825 of the gene encoding for the beta3 subunit of heterotrimeric G proteins (GNB3) is associated with enhanced coronary constriction after intracoronary administration of methylergonovine. The 825T allele has also been shown to be associated with an enhanced response after activation of G protein coupled receptors. Since most vascular receptors belong to this family of heptahelical receptors, the underlying hypothesis appears conclusive, and, thus, nicely confirms our own results in connection with an enhanced coronary vasoconstrictor response after alpha-adrenoceptor activation in carriers of the 825T allele at GNB3. First, we would like to congratulate the authors on their interesting and